BALTIMORE - One bad inning did in Pedro Martinez, just like last October.

Javy Lopez homered and drove in three runs, and fellow newcomers Rafael Palmeiro and Miguel Tejada both had two hits to lead the Orioles over the Boston Red Sox 7-2 Sunday night in Lee Mazzilli's first game as Baltimore's manager.

Martinez experienced an uncharacteristic lapse in control while yielding three second-inning runs. The Red Sox fell behind the New York Yankees (1-1) in the AL East for the first time this season by virtue of the opening-night loss.

Signed as free agents during a busy winter for the Orioles, Lopez, Palmeiro and Tejada combined to go 7-for-11 with three runs and four RBIs. Tejada was also perfect on 12 chances at shortstop.

Martinez was the loser, giving up three runs, two earned, and seven hits in six innings. He struck out five, walked one and hit a batter.

It was his first appearance in a game that counted since Oct. 16, when the three-time Cy Young Award winner blew a 5-2 against the Yankees in Game 7 of the AL championship series, and New York went on to win 6-5 in 11 innings.

Boston ultimately fired manager Grady Little for, among other things, leaving a tiring Martinez in too long.