Reserve Preston Knowles scored 19 points to lead No. 5 Louisville to a 99-54 victory over DePaul on Sunday, the Blue Demons’ 13th straight loss to match their worst streak ever.

Reginald Delk, making his first career start, had 10 points for the Cardinals (19-5, 10-2 Big East), who had a season-high 18 3-pointers, including five by Knowles. Delk started in place of Terrence Williams, who had been playing with an injured right wrist.

Williams, Louisville’s best all-around player, played 15 minutes had five assists and two rebounds and did not take a shot.

Dar Tucker had 17 points for DePaul (8-18, 0-13), while Mac Koshwal had 12 points and 10 rebounds.

The Cardinals scored the first 13 points of the game and went on to a 51-21 halftime lead.

Boston College 80, No. 6 Duke 74

BOSTON (AP) — Reggie Jackson broke the game’s final tie with a drive with 47.2 seconds left and Boston College scored the final six points for its first win over Duke in 24 years.

Tyrese Rice had 21 points, including a key 3-pointer, and Joe Trapani added 20 for the Eagles (19-8, 7-5 Atlantic Coast Conference). Jackson finished with 15 points.

Kyle Singler had 25 points for the Blue Devils (20-5, 7-4), who have lost three of four, while Gerald Henderson added 20.

The Eagles snapped an eight-game losing streak to Duke. BC’s last win over the Blue Devils came on March 17, 1985.

It was BC’s second win over a highly ranked team this season. The Eagles handed then-No. 1 North Carolina its first loss, 85-78, in Chapel Hill on Jan. 4.

Virginia 85, No. 12 Clemson 81, OT

CHARLOTTESVILLE, Va. (AP) — Sylven Landesberg scored six of his 23 points in overtime and Virginia ended an eight-game losing streak.

Landesberg’s driving basket with 13.4 seconds left in regulation tied it at 74, and he had the last six points in a 10-5 run to start the extra period for the Cavaliers (8-13, 2-8 Atlantic Coast Conference), whose only other league victory came in overtime at Georgia Tech.

Terrence Oglesby had 17 points, including five 3-pointers, for the Tigers (20-4, 6-4), but his leaning attempt with about 8 seconds left was well off the mark.

Loyola of Chicago 71, No. 15 Butler 67

INDIANAPOLIS (AP) — Freshman Jordan Hicks scored a career-high 23 points and Loyola of Chicago snapped a six-game losing streak.

The Ramblers (13-15, 5-11 Horizon League) notched their first win over a ranked opponent since a 75-71 victory at Butler two years ago. The loss prevented the Bulldogs (22-3, 13-2) from clinching at least a share of their third straight conference regular-season championship.

Matt Howard, who scored a career-high 30 points for Butler, led a comeback that brought the Bulldogs within 69-67 with 31 seconds left, but Justin Cerasoli hit two free throws with 4 seconds remaining to seal the win.

No. 22 Illinois 65, Indiana 52

BLOOMINGTON, Ind. (AP) — Mike Tisdale and Mike Davis both scored 16 points and Illinois held off Indiana’s second-half rally.

The Fighting Illini (21-5, 9-4 Big Ten) won their third straight overall and improved to 10-4 against the Hoosiers in the last 14 games.

Matt Roth had 13 points for Indiana (6-18, 1-11), which couldn’t avoid setting another dubious school record — becoming the first Hoosiers team to lose 18 games in a season. The 1969-70 team lost 17 games and set the school record for Big Ten losses (11), a mark this Indiana team has tied.

The Hoosiers, who trailed by as many as 21 points, got within 54-48, but Illinois went on an 11-4 over the final 5 minutes.