Wondering about the best bet among all 49 FBS matchups in Week 6? Our choice, in terms of the point spreads, is Marshall at -1.5 — but scroll down, because we have lots more suggestions, which could lead to parlay opportunities.

Get computer predictions and insights for that matchup and more in this article.

BetMGM is one of the most trusted Sportsbooks in the nation. Start with as little as $1 and place your bets today.

College Football Computer Picks – Best Spread Bets

Watch college football this season on Fubo and ESPN+.

Pick: Marshall -1.5 vs. Appalachian State

• Matchup: Appalachian State Mountaineers at Marshall Thundering Herd
• Projected Winner & Margin: Marshall by 22.6 points
• Time: 3:30 PM ET
• Date: Oct. 5
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Pick: Boise State -27.5 vs. Utah State

• Matchup: Utah State Aggies at Boise State Broncos
• Projected Winner & Margin: Boise State by 47.2 points
• Time: 7:00 PM ET
• Date: Oct. 5
• TV Channel: Fox Sports 2
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Army -10.5 vs. Tulsa

• Matchup: Army Black Knights at Tulsa Golden Hurricane
• Projected Winner & Margin: Army by 28 points
• Time: 12:00 PM ET
• Date: Oct. 5
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Charlotte +7.5 vs. East Carolina

• Matchup: East Carolina Pirates at Charlotte 49ers
• Projected Winner & Margin: Charlotte by 9.7 points
• Time: 3:30 PM ET
• Date: Oct. 5
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Duke +8.5 vs. Georgia Tech

• Matchup: Duke Blue Devils at Georgia Tech Yellow Jackets
• Projected Winner & Margin: Duke by 6.7 points
• Time: 8:00 PM ET
• Date: Oct. 5
• TV Channel: ACC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Use these spread picks at BetMGM today!

College Football Computer Picks – Best Total Bets

Over 36.5 – Navy vs. Air Force

• Matchup: Navy Midshipmen at Air Force Falcons
• Projected Total: 52.7 points
• Time: 12:00 PM ET
• Date: Oct. 5
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Under 46.5 – Hawaii vs. San Diego State

• Matchup: Hawaii Rainbow Warriors at San Diego State Aztecs
• Projected Total: 35.8 points
• Time: 8:00 PM ET
• Date: Oct. 5
• TV Channel: CBS Sports Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 48.5 – James Madison vs. Louisiana-Monroe

• Matchup: James Madison Dukes at Louisiana-Monroe Warhawks
• Projected Total: 56.8 points
• Time: 7:00 PM ET
• Date: Oct. 5
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 54.5 – Wake Forest vs. North Carolina State

• Matchup: Wake Forest Demon Deacons at North Carolina State Wolfpack
• Projected Total: 61.8 points
• Time: 12:00 PM ET
• Date: Oct. 5
• TV Channel: The CW
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 46.5 – Purdue vs. Wisconsin

• Matchup: Purdue Boilermakers at Wisconsin Badgers
• Projected Total: 53.8 points
• Time: 12:00 PM ET
• Date: Oct. 5
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Take advantage of our picks and place your bet at BetMGM today!

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.