JACKSONVILLE, Fla. (AP) — Louis Dale scored 26 points and Ryan Wittman had 24, helping 12th-seeded Cornell dominate No. 4 seed Wisconsin 87-69 on Sunday to reach the round of 16 in the NCAA tournament for the first time.

The Big Red entered the tourney with no victories in four previous appearances and upset fifth-seeded Temple in the opening round. They are the first Ivy League team to advance to the round of 16 since Penn in 1979.

Next up, top-seeded Kentucky in the East Regional semifinals.

Cornell (29-4) shot 59 percent from the field to build a 43-31 halftime lead. Wisconsin (24-9) never made a serious run, falling behind by 20 points midway through the second half.

Jon Leuer led the Badgers with 23 points while Jason Bohannon had 18 and Trevon Hughes 10.

No. 2 West Virginia 68,

No. 10 Missouri 59

BUFFALO, N.Y. (AP) — Da’Sean Butler accounted for 19 of West Virginia’s 30 points in the first half, then finished with 28 to lead the second-seeded Mountaineers past No. 10 Missouri and into the round of 16.

Kevin Jones had 13 points and nine rebounds for the Big East Conference tournament champions.

Michael Dixon scored 15 points for Missouri (23-11), which went 20 of 61 from the field and was just as bad from the free-throw line, going 12 of 20.

West Virginia (29-6) advances to face No. 11 seed Washington at Syracuse, N.Y., on Thursday. It marks the fifth time the Mountaineers reached the final 16, and first since 2008.

MIDWEST REGIONAL

No. 5 Michigan State 85, No. 4 Maryland 83

SPOKANE, Wash. (AP) — Korie Lucious hit a 3-pointer at the buzzer to cap a frenetic finish and give injury-depleted Michigan State, which lost star guard Kalin Lucas, a victory over Maryland.

The Spartans blew a 16-point lead in the second half. Greivis Vasquez put fourth-seeded Maryland (24-9) ahead 83-82 with 6 seconds left, but Michigan State pushed the ball up the floor and Lucious, filling in for Lucas, drained a 3 from the top of the key, setting off a wild celebration by the Spartans.

No. 5 seed Michigan State (26-8) advanced to play ninth-seeded Northern Iowa on Friday in the Midwest Regional semifinals in St. Louis.

Lucas, a two-time all-Big Ten selection, got hurt with 2:28 remaining in the first half and did not return.

Spartans coach Tom Izzo said the junior likely has a torn Achilles’ tendon, which would make it almost impossible for him to play in the round of 16 — and probably would sideline him for the rest of the tournament.

WEST REGIONAL

No. 1 Syracuse 87, No. 8 Gonzaga 65

BUFFALO, N.Y. (AP) — Wes Johnson scored a career-high 31 points and pulled down 14 rebounds, and Andy Rautins added 24 points as top-seeded Syracuse hit a dozen 3-pointers to rout No. 8 Gonzaga.

It’s been a storybook campaign for the Orange (30-4), who were unranked before the season and made it to No. 1 for the final week before losing to Georgetown in the Big East tournament. They play Thursday in the round of 16 against fifth-seeded Butler in Salt Lake City.

Elias Harris led Gonzaga (27-7) with 24 points.

No. 6 Xavier 71, No. 3 Pittsburgh 68

MILWAUKEE (AP) — Jordan Crawford scored 27 points, including a breakaway dunk with just over two minutes remaining, to help sixth-seeded Xavier beat No. 3 Pittsburgh in the second round.

Jason Love had 14 points and a key block down the stretch for the Musketeers (26-8), who advanced to play second-seeded Kansas State in the West Regional semifinals in Salt Lake City on Thursday.

Ashton Gibbs scored 19 points and Brad Wanamaker had 16 points and 10 rebounds for the Panthers (25-9), who nearly rallied with two 3-pointers by Gilbert Brown in the final 28 seconds.

Gibbs missed a potential game-tying 3-pointer with less than a second left. Pittsburgh had one last chance to inbound the ball with 0.4 seconds left, but Wanamaker left the shot short.

SOUTH REGIONAL

No. 1 Duke 68, No. 8 California 53

JACKSONVILLE, Fla. (AP) — Nolan Smith scored 20 points, Kyle Singler added 17 and top-seeded Duke reached the round of 16 by beating California.

Brian Zoubek finished with 14 points and 13 rebounds — the sixth double-double of his career — as the Blue Devils overcame some long-range shooting woes with dominant post play.

Duke (31-5) advanced to play No. 4 seed Purdue in a South Regional semifinal Friday in Houston.

The eighth-seeded Golden Bears (24-11) failed to get past the opening weekend for the fourth time in as many NCAA tournament appearances.

No. 4 Purdue 63, No. 5 Texas A&M 61, OT

SPOKANE, Wash. (AP) — Chris Kramer’s drive past one defender and layup over another 6 inches taller than him with 4.2 seconds remaining in overtime sent fourth-seeded Purdue into the regional semifinals with a bruising victory over No. 5 Texas A&M.

B.J. Holmes got a final, frantic chance to win the game for Texas A&M with a rushed 3-point try from in front of his bench at the buzzer, but it hit short on the rim to ensure a sixth regional appearance in 12 NCAA tournaments dating to 1994 for Purdue (29-5).

Kramer, Purdue’s leader with Robbie Hummel out with a knee injury, led the Boilermakers with 17 points and seven rebounds.

Bryan Davis led the Aggies (24-10) with 17 points and 15 rebounds. The 6-foot-9 senior was the man who leaped but could not block Kramer’s winning shot.