Top 25 College Hoops Picks Against the Spread – Tuesday, January 21

Published 1:28 am Tuesday, January 21, 2025

There are 12 games featuring a ranked team on the Tuesday college basketball schedule, including the Mississippi State Bulldogs versus the Tennessee Volunteers. If you’re seeking against-the-spread picks for each matchup, continue reading.

Place your bets on any men’s college basketball matchup at BetMGM. Sign up today using our link.

AP Top 25 Picks ATS Today

No. 4 Alabama Crimson Tide vs. Vanderbilt Commodores

Spread Prediction

  • Computer Prediction: Alabama 85, Vanderbilt 74
  • Projected Favorite: Alabama by 10.3 points
  • Pick ATS: Vanderbilt (+11.5)

Email newsletter signup

Bet on the Alabama-Vanderbilt spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Tuscaloosa, Alabama
  • Venue: Coleman Coliseum
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 6 Tennessee Volunteers vs. No. 14 Mississippi State Bulldogs

Spread Prediction

  • Computer Prediction: Tennessee 76, Mississippi State 68
  • Projected Favorite: Tennessee by 7.5 points
  • Pick ATS: Tennessee (-7.5)

Bet on the Tennessee-Mississippi State spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Knoxville, Tennessee
  • Venue: Thompson-Boling Arena
  • TV Channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 19 UConn Huskies vs. Butler Bulldogs

Spread Prediction

  • Computer Prediction: UConn 77, Butler 69
  • Projected Favorite: UConn by 7.6 points
  • Pick ATS: Butler (+12.5)

Bet on the UConn-Butler spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Hartford, Connecticut
  • Venue: XL Center
  • TV Channel: Fox Sports 1
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 11 Purdue Boilermakers vs. Ohio State Buckeyes

Spread Prediction

  • Computer Prediction: Purdue 78, Ohio State 70
  • Projected Favorite: Purdue by 7.3 points
  • Pick ATS: Ohio State (+10.5)

Bet on the Purdue-Ohio State spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:30 PM ET
  • Location: West Lafayette, Indiana
  • Venue: Mackey Arena
  • TV Channel: Peacock
  • Live Stream: Peacock

No. 7 Houston Cougars vs. Utah Utes

Spread Prediction

  • Computer Prediction: Houston 79, Utah 61
  • Projected Favorite: Houston by 17.7 points
  • Pick ATS: Houston (-17.5)

Bet on the Houston-Utah spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8:00 PM ET
  • Location: Houston, Texas
  • Venue: Fertitta Center
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

No. 3 Iowa State Cyclones vs. UCF Knights

Spread Prediction

  • Computer Prediction: Iowa State 83, UCF 70
  • Projected Favorite: Iowa State by 12.6 points
  • Pick ATS: UCF (+15.5)

Bet on the Iowa State-UCF spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8:00 PM ET
  • Location: Ames, Iowa
  • Venue: James H. Hilton Coliseum
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

Seton Hall Pirates vs. No. 10 Marquette Golden Eagles

Spread Prediction

  • Computer Prediction: Marquette 77, Seton Hall 63
  • Projected Favorite: Marquette by 14.1 points
  • Pick ATS: Marquette (-12.5)

Bet on the Seton Hall-Marquette spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8:00 PM ET
  • Location: Newark, New Jersey
  • Venue: Prudential Center
  • TV Channel: Peacock
  • Live Stream: Peacock

SMU Mustangs vs. No. 25 Louisville Cardinals

Spread Prediction

  • Computer Prediction: Louisville 77, SMU 76
  • Projected Favorite: Louisville by 0.1 points
  • Pick ATS: Louisville (+1.5)

Bet on the SMU-Louisville spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:00 PM ET
  • Location: Dallas, Texas
  • Venue: Moody Coliseum
  • TV Channel: ACC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 23 West Virginia Mountaineers vs. Arizona State Sun Devils

Spread Prediction

  • Computer Prediction: West Virginia 74, Arizona State 68
  • Projected Favorite: West Virginia by 5.9 points
  • Pick ATS: Arizona State (+7.5)

Bet on the West Virginia-Arizona State spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:00 PM ET
  • Location: Morgantown, West Virginia
  • Venue: WVU Coliseum
  • TV Channel: CBS Sports Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Texas Longhorns vs. No. 22 Missouri Tigers

Spread Prediction

  • Computer Prediction: Missouri 76, Texas 75
  • Projected Favorite: Missouri by 0.0 points
  • Pick ATS: Missouri (+2.5)

Bet on the Texas-Missouri spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:00 PM ET
  • Location: Austin, Texas
  • Venue: Moody Center
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

UCLA Bruins vs. No. 18 Wisconsin Badgers

Spread Prediction

  • Computer Prediction: UCLA 74, Wisconsin 73
  • Projected Favorite: UCLA by 0.2 points
  • Pick ATS: Wisconsin (+3.5)

Bet on the UCLA-Wisconsin spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:30 PM ET
  • Location: Los Angeles, California
  • Venue: Pauley Pavilion
  • TV Channel: Peacock
  • Live Stream: Peacock

No. 15 Oregon Ducks vs. Washington Huskies

Spread Prediction

  • Computer Prediction: Oregon 78, Washington 68
  • Projected Favorite: Oregon by 9.3 points
  • Pick ATS: Washington (+12.5)

Bet on the Oregon-Washington spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 11:00 PM ET
  • Location: Eugene, Oregon
  • Venue: Matthew Knight Arena
  • TV Channel: BTN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.

id: