PHOENIX (AP) — Johnny Cueto had dominated the Diamondbacks — until Friday night.

The right-hander had his worst outing in three seasons, giving up seven runs over 4 1-3 innings as the Cincinnati Reds lost 11-5 to Arizona. The 11 hits off Cueto matched his career worst.

“Things did not go well,” Cueto said through a translator. “It is just one outing but a bad outing. I have a lot more outings, so I have to keep my head up and continue.”

Arizona slugger Paul Goldschmidt had his third two-homer game of the season to lead the Arizona’s offense.

Reds manager Dusty Baker said Cueto, making his second start since coming back from his second stint on the disabled list this season, simply wasn’t his usual self.

“He was getting balls over the heart of the plate,” Baker said. “His slider wasn’t as sharp. The one he threw to Goldschmidt spun like a cement mixer instead of really breaking.”

Cueto had been 5-0 with a 1.66 ERA in his six starts against the Diamondbacks. The seven runs he allowed Friday equaled the total he gave up combined in his six other starts against them.

The Reds, making a cross-country trek after splitting four games against Pittsburgh, had counted on a much longer outing from Cueto.

“The timing of it all wasn’t good because our bullpen was already beat up when we came in here,” Baker said. “We were hoping to get quite a few innings out of Johnny tonight and get our bullpen back right for the next couple of days and the off day.”

Goldschmidt drove in three runs to raise his NL-leading RBI total to 65. Gerardo Parra hit a leadoff home run for Arizona and Jason Kubel tied his career high with four hits.

Kubel doubled in a run and scored twice.

Arizona had not scored more than four runs in any of its previous six games.

“That was a great job tonight up and down the lineup,” Goldschmidt said. “We’ve got the talent to do it, and I think we’re going to do it. It’s just part of the game. It’s up and down sometimes. Sometimes we’re going to struggle and sometimes we’re going to hit the ball well.”

Cueto (4-1) had not allowed this many runs since Milwaukee scored eight against him on Sept. 22, 2010.

Jay Bruce hit his 150th career home run for the Reds. Joey Votto drove in two runs with a long homer and a double.

Will Harris (1-0) got one out in relief of starter Wade Miley to get the victory.

Goldschmidt has four home runs in four games and 19 for the year, one fewer than he had last season. He hit a two-run shot off Cueto in the fifth and a solo homer off Curtis Partch in the sixth that traveled an estimated 457 feet, making it the longest of Goldschmidt’s career.

“He’s huge for our team,” manager Kirk Gibson said. “I don’t think anybody else has over 20-some RBIs, Goldy’s in the 60s. He’s the nucleus of our team, certainly offensively. He’s dependable, takes care of himself properly and he keeps pushing on.”

Things began badly for Cueto when Parra pulled Cueto’s 2-2 pitch into the right-field seats for his fifth career leadoff home run, all this season.

In the second, Kubel led off with a single, then Didi Gregorius singled with one out to put runners at first and second. Miley struck out, but Parra walked to load the bases. Willie Bloomquist, hitless in his previous 11 at-bats, singled to bring in two runs and Arizona led 3-0.

In the fourth, Bruce hit Miley’s 0-1 pitch far into the seats in right field for his 16th home run to cut it to 3-1.

The Reds tied it in the fifth. Cueto beat out a bunt single, his second hit of the year, moved to second when Shin-Soo Choo walked and scored on Votto’s double into the left-field corner.

Choo scored when Brandon Phillips hit the ball sharply to Gregorius at shortstop. Gregorius couldn’t make the play and was charged with an error. Phillips was credited with an RBI, and it was 3-all.

Bloomquist led off the Arizona fifth with a single, then Goldschmidt hit one to the opposite field over the fence in right to put the Diamondbacks back on top for good, 5-3. Miguel Montero followed with a single, then after Cody Ross struck out, Kubel singled and Cueto’s night was finished.

Martin Prado’s sacrifice fly off reliever J.J. Hoover made it 6-3. Kubel came home on Hoover’s wild pitch, and Arizona got four in the sixth off Partch to lead 11-3.

Votto’s solo home run came against Tony Sipp in the seventh.

NOTES: The 11 runs were the second-most allowed by the Reds this season. … Cueto’s outing matched his shortest of the season. … On Saturday night, in the series’ prime pitching matchup, the Reds send Mike Leake (7-3, 2.64 ERA) to the mound and Arizona goes with Patrick Corbin (9-0, 2.28). Corbin will make his fourth try to go to 10-0 after no-decisions in his last three starts. … Bruce has homered in six of his last eight games.